5-HTP Dosage: What is a Safe and Effective Usage Range?

5-HTP (5-Hydroxytryptophan, Oxitriptan) is a supplement used to improve mood, reduce anxiety and stress, suppress the appetite, and promote better sleep. This chemical compound is also a naturally occurring amino acid and serves many important roles in the body. It acts as a metabolic intermediate in the breakdown of tryptophan to produce serotonin and melatonin. While some people take tryptophan supplements for mood enhancement and appetite suppression purposes, using a 5-HTP dosage avoids one of the metabolic steps and is therefore more potent.

Using 5-HTP supplements will increase levels of the serotonin and melatonin inhibitory neurotransmitters in the brain. Serotonin is important in digestion as it promotes peristalsis and is also responsible for feelings of “happiness” and “well-being,” whereas melatonin is a hormone whose circulation is key in maintaining circadian rhythm (also known as the “Biological Clock”) in animals. This is important for regulating sleep patterns, hence why 5-HTP dosages can be prescribed in order to combat insomnia. It can also be used in a nootropic stack to address indirect factors related to cognitive function such as mood and sleep quality.

In terms of natural diet, human intake of 5-HTP is insignificant. However, the essential amino acid that it aids in metabolising (tryptophan) is a common constituent of most protein-based foods. It is found in foods like red meat, poultry, potatoes, milk, pumpkins and various green vegetables. Tryptophan is an essential amino acid, meaning that it cannot be synthesised by the human body and must be acquired from dietary sources such as those listed above. But taking an equivalent dose of Tryptophan will not lead to the same end result as taking 5-HTP. Tryptophan is subject to a rate-limiting factor that prevents excess amounts being taken up by the brain and turned into active neurotransmitters. 5-HTP dosages are known to be more effective because they bypass this rate limit, allowing you to increase serotonin levels beyond your pre-programmed biochemical norm.

Where does 5-HTP come from?
5-htp dose5-HTP is typically sourced from the plant Griffonia simplicifolia. This makes 5-HTP a natural nootropic. This is a climbing shrub that is found in West and Central Africa, and its seeds are harvested for their 5-HTP. Griffonia simplicifolia can grow up the 3 meters high and bears green flowers.
What does 5-HTP do? 5-HTP aids in the metabolic breakdown of tryptophan into serotonin and melatonin. As such can be used to treat things such as depression, anxiety and any problems that a patient may be having with their sleep patterns. Serotonin aids in depression by causing feelings of happiness, hence 5-HTP’s action as an antidepressant, and as stated above melatonin plays a role in the maintenance of a regular circadian rhythm. 5-HTP can be used as part of a nootropic stack for relaxation, improved sleep and even as a lucid dreaming aid.

What is the recommended 5-HTP dosage?
5-HTP capsules are sold over the counter in the United States, United Kingdom and Canada, typically in 50mg or 100mg gelatine encased tablets. The recommended dosage for 5-HTP will vary based on the ailment that it is being taken for. Since 5-HTP can be used to treat many problems, such as sleep issues, anxiety or depression, knowing which dose is required for you is essential.
It is very important to note that 5-HTP can be dangerous if taken at exceptionally high doses, and anyone considering taking it should seek medical advice and always read the label and any accompanying instructions carefully. 5-HTP is not generally suitable for use by children under the age of 18.

For sleep problems, some sources recommend a dose of 200mg taken before bedtime, and taken with 8 ounces of water. For anxiety, 5-HTP dosage is recommended at a 50mg capsule each day, but can be increased if advised to do so by a doctor. Some sources even recommend taking these capsules three times a day, but a doctor will be able to advise the appropriate dosage on a case-by-case basis.

The recommended dosage for 5-HTP also varies with health and age, though unfortunately no reliable sources of these guidelines are currently available. As such, anyone considering taking 5-HTP for anxiety, depression or sleep issues should consult their doctor before starting, so that they can be sure that they are receiving the correct dosage.

For headaches, sources say that on average 300-600mg can be taken daily by mouth in divided portions. An amount this high should not be taken on an on-going basis. Again, these will vary at the discretion of a medical professional. For hot flashes, 150mg are recommended to be taken orally on a daily basis for up to four weeks.

Is it possible to overdose?
5-htp overdoseAs with any medication, overdose is a concern and 5-HTP is no exception. Symptoms of an overdose can include:

• Tachycardia (increased heart rate)
• Hallucinations
• Sweating
• Dizziness or feeling faint
• Muscle twitching
• Diarrhoea

Anyone experiencing any of these symptoms and fears that they may have an overdose of 5-HTP, should seek medical attention immediately and should receive supportive care.

There is also concern that high intake of 5-HTP can cause serotonin syndrome. In addition, taking 5-HTP in conjunction with antidepressants of the MAOI (Monoamine oxidase inhibitor) or SSRI (Selective serotonin re-uptake inhibitor) classes can also cause serotonin syndrome, which is a serious condition that is a form of poisoning and can be potentially life threatening.

All in all, anyone considering taking 5-HTP should consult their doctor first in order to make sure they are not taking any drugs that it may interact with and also that they are prescribed the correct dosage for their particular problem. While 5-HTP does offer a lot of potential benefits, there are some serious dangers that can occur if it is abused. Only a medical professional who is informed as to your personal medical history can help you decide on the right 5-HTP dosage.

History of Nootropics

Understanding the modern phenomenon of smart drugs has been a challenge for many people. Even the term “nootropics” seems to be alien and somewhat difficult to write or pronounce. However, the history of the neuro enhancers is a fascinating one and something that has yet to be told. The following article will provide you some background into how nootropics were originally found, why they are being used, and how it has changed over time. The nootropic scene today looks quite different from a few years ago and even more so than when first found.

Nootropics in 1970s

The first nootropic drug was found in the 1960s and utilized first as a tool to help people with motion sickness. After that episode, the drug was tested for memory enhancement. In 1971 the first studies were done on piracetam as a nootropic drug that could improve memory. With the advent of this drug, the term “nootropics” was actually coined by a Romanian doctor named Dr. Corneliu Giurgea. With his tests on piracetam, he decided to use a Greek combination of “nous” meaning “mind” and “trepein” meaning “to bed”. Literally, the drugs were able to help bend the mind.

Since then, the studies of piracetam have been done all around the world to focus on specific aspects. Understanding whether racetams can help to improve memory with choline, testing neuro protective benefits with Alzheimer’s patients, and much more. The tests expanded to other analogues of piracetam, such as aniracetam and oxiracetam, where studies remained equally upbeat.

However, this was but a small fraction of the nootropic drugs studied over the past few decades. At first the studies were done on rats and animals to test whether it was a statistically significant improvement. Then toxicity studies came and finally they were done on willing human patients. As people have found the nootropic drugs, they have been wary without the adequate proof.

Nootropics Today

Today, people are realizing that the nootropic drugs are far more useful and less risky than ever before. The many decades of tests have proven how important the drugs can be not only for people who want to enhance their lives, but also those who want to just be healthy in general.

Neuro enhancing drugs can be incredibly effective for anyone who is trying to get ahead in the modern world. Just a few years ago it wasn’t even that popular as it was taboo to take the drugs outside of a prescription. Today it seems a lot more interesting to get involved within the industry and even partake in the pills themselves.

Are Nootropics for You?

In determining whether you want to take nootropics or not, it is a good idea for you to make sure you know about your goals. For those who just want to be healthy, it might be enough to supplement with some choline. Those who want to pass all of the medical exams might need to buy piracetam or find other methods of enhancing their memory retention and concentration while they are studying.

Best Nootropics for the Elderly

Even though the people who have popularized the best nootropics are youth, there are plenty of great drugs that can help older people as much. In fact, some of the smart drugs being used by millions of college students around the world could be used more or as effectively with adults. The racetam line of neuro enhancers are well known to help people to protect their neurological connections and to improve the memory retention. Older people who are suffering from age-related neuronal loss (loss of memory, senile dementia, Alzheimer’s disease etc.) can all benefit from using these nootropic drugs.

Best Nootropics to Start

Elderly people or family members who understand the benefits of piracetam will be eager to start. Improving memory in many of these people is the highest priority as it can mean the difference between an extended enjoyable life and a slow decrepit decline. Most elderly people will have some form of neuronal loss as they get older and the best nootropics can help to prevent that.

People who are starting off with piracetam or other racetams should make sure they don’t have a huge dosage and do not go without using choline. Using choline in addition to the piracetam will help to improve the results and provide mitigation against many of the headaches and other problems that occur when there is a depletion of acetylcholine.
Starting off with 1 gram piracetam capsules twice a day can have a huge impact on memory in the short and long-term. Take some choline products as well to ensure there is a synergy between the two. Once you have done that, there is a good chance you will be able to start seeing results in only a few days. Some people instantly see results when it comes to the vivid nature of their dreams.

Racetams for Elderly Memory Enhancement

There are other racetams that can help for elderly patients as well, but the studies are less clear. The piracetam powder was found first and therefore has the most studies. Aniracetam and oxiracetam have their own advantages, but fewer studies that can back them up and provide a convincing argument. For those who want to start, the piracetam is probably the best choice.

However, if you have started with piracetam and find that there are not as many improvements as you would like, then it might be a good idea to look for memory enhancement through the other analogues. Both aniracetam and oxiracetam have totally different properties even though they are similar in their chemical composition and structure. If you want to get started with elderly memory enhancement you can even use nootropic stacks together so that you can get the best of both worlds.

Using Best Nootropics with Elderly Patients

The best nootropics are the ones that can help not only the young adults who are trying to get through college, but also the elderly who are suffering from Alzheimer’s disease and other memory related problems. By starting with the piracetam substance, you can help elderly people or yourself to enjoy better memory and prevent degradation of memories.

How Sulbutiamine Can Help You Maintain Optimal Health and Increase Your Energy to Feel Years Younger

Did You Know…?

Sulbutiamine is the generic name for Arcalion, a supplement use primarily for increasing energy.  Many people who suffer from a lack of energy use sulbutiamine [1].

What is sulbutiamine?

Sulbutiamine is a form of Vitamin B1 that originated from Japan. Sulbutiamine improves energy, memory, and is used to help those with erectile dysfunction along with the many other benefits [4]. Its popularity has soared in recent years.

Sulbutiamine Benefits

  • Improves memory and cognition: Studies have demonstrated that the use of sulbutiamine improves memory through the potentiation of cholinergic and dopaminergic transmission.[2]
  • Improve reflexes [5]
  • Improves your ability to focus [5]
  • Improves fatigue [1]
  • Improves mood [3]
  • Can help with erectile dysfunction [4]
  • Used as an appetite suppressor [6]
  • Weight loss: Burns fat to help reduce body weight [6]

The benefits of this supplement are outstanding.  It has the ability to improve neurotransmission; it can help improve reflexes, attention and mental alertness. It is also helpful to those with asthenia – a form of chronic fatigue that is based on cognitive function rather than being muscular in origin [1].  Sulbutiamine also can improve a person’s mood[3]. People also use sulbutiamine to alleviate stress. Recent studies have suggested that sulbutiamine may help those with erectile dysfunction [4]. Some users take sulbutiamine as an appetite suppressor and fat burner to help reduce body weight.  It is truly the jack-of-all-trades.


  1. www.ncbi.nlm.nih.gov/pubmed/9843061
  2. www.sciencedirect.com
  3. www.ncbi.nlm.nih.gov/pubmed/10858919
  4. link.springer.com
  5. link.springer.com
  6. www.healthguidance.org

The Best Nootropics For Depression and Mood Boosting

Taking Nootropics for depression and mood enhancement is very common along with the many other benefits for cognitive function and brain health. Sadly, mood problems, anxiety, and depression affect many people these days. Recent estimates have placed this number as high as 10 percent of the population, not counting those who have temporary mood issues like Seasonal Affective Disorder or those who have very mild symptoms. While just taking pills or supplements will not be the answer for everyone a good number of people, especially those with milder symptoms, could benefit from adding a number of nootropics into their supplementation routine.  But which are the best nootropics for depression to help with these issues? Are there any associated side effects? This article will take you through the best nootropics for mood enhancement and related issues.


This supplement is a member of the racetam family and has become well-known for its mood boosting properties . It is fat soluble, so it is best to take it with food. Many users have reported that one of the main effects with this racetam is that they feel stimulated, with a great amount of positive mental energy, concentration and focus. This energy can also be helpful in motivation which is definitely something that people with depression-like symptoms have as problem.

There are also additional effects with Aniracetam supplements, such as helping to increase blood flow to the brain. It is believed to act on several powerful brain chemicals known as Neurotransmitters. There is even some speculation that it might help to increase communication between the two hemispheres of the brain. Many users also swear by this one as a way to help positively influence creativity and holistic thinking.


Sulbutamine is technically a member of the B family of vitamins, although it does act very similar to a nootropic in many ways. This supplement is a modified version of thiamine that is known to possess a number of anti-anxiety and anti-depression qualities. It is even prescribed in many foreign countries as a treatment for both of these (and related) conditions.

This supplement works by effectively crossing the blood-brain barrier and increase levels of thiamine and related substances. This enhances the ability of brain neurons to communicate and is believed to have positive effects on choline, dopamine, and glutamate, three of the most powerful brain chemicals that play a role in mood and movement operations. Many people report that this supplement helps to relieve stress, fatigue, attention, and mental alertness. All of these can be incredibly helpful benefits to those suffering from anxiety and mild depression related symptoms.



Noopept is one of the most powerful nootropics available. It has mood boosting effects that are similar to Aniracetam, only a bit more potent. It is very fast acting due to the fact that it absorbs quickly and easily crosses the blood-brain barrier; oftentimes effects are felt within fifteen minutes. There is a lot of anecdotal evidence to support that taking this supplement increases brain energy and motivation.

In fact, experienced nootropic users indicate that this may be the most effective motivation supplement.


A number of studies indicate that Noopept acts as a neuroprotective. Meaning that it helps to keep the neurons in the brain healthy. In some cases, it may even be able to reverse existing damage. This is perhaps why it is so effective at boosting mood and helping to alleviate stress and symptoms of anxiety and depression. It is also believed that this supplement helps to increase and even build connections within the brain, meaning that this might be an effective long-term solution for sustaining a number of these beneficial effects.



Once again, this supplement is not a true nootropic. Inositol is well regarded as a member of the vitamin B family, but does seem to have positive effects on anxiety improvement. It works by crossing the blood-brain barrier and then helping to increase the production of GABA, another powerful brain chemical. Additionally, it may help to increase the effectiveness of other medications designed to help boost GABA levels by enhancing their binding properties to receptor sites.

As levels of GABA increase within the brain you should notice a feeling of calm and well-being. This supplement also helps to reduce stress levels and promote normal sleep patterns. This is an excellent natural solution for those who suffer from mild anxiety and depression as well as sleep issues.


There are many other nootropics that can help with mood and depression. The real test however, is to discover what specific effects they have on you. Take a look at the descriptions of each drug and give one (or all) of them a try.

What do you think the best nootropic or nootropic stack is for depression?